De ellos 214 precisaron ventilación mecánica. Han sido criterios de exclusión la edad inferior a 18 años, enfermos ventilados a través de traqueotomía y enfermos considerados no colaboradores por diversas causas.ĭurante el periodo de estudio, ingresaron en UCIG 392 enfermos. Se han incluido en el estudio aquellos enfermos que recibían VM por un espacio de tiempo superior a las 12 horas y quienes en el proceso de destete seguían un protocolo de presión soporte de bajo nivel. Unidad de cuidados intensivos generales (UCIG), del complejo hospitalario de tercer nivel Hospital Universitario Marqués de Valdecilla. Desde el 1 de septiembre de 2010 hasta 1 de marzo de 2011. DiseñoĮstudio de cohortes, prospectivo, observacional. Vd/ Vt is a powerful predictor of extubation failure in patients on MV.Ĭomprobar qué valor tiene la fracción de espacio muerto (Vd/Vt) como predictor del fracaso en la extubación de los enfermos que necesitaron ventilación mecánica (VM) ingresados en las unidades de cuidados intensivos. The area under the ROC curve with respect to the prediction of extubation failure according to the Vd/ Vt value was 0.94 (95%CI 0.86–0.98, p < 0.0001). Logistic regression analysis showed a significant association between the Vd/ Vt and extubation failure, with OR = 1.52 (95%CI 1.11–2.09, p = 0.008). Vd/ Vt was calculated as the ratio ( PaCO 2 − PeCO 2)/ PaCO 2, with the recorded parameters.

A total of 76 patients were finally extubated and analyzed. Fifty-four patients were excluded from the study, and 24 were not extubated from MV. The weaning process was started in 154 cases. Exclusion criteria were age under 18 years, ventilation via tracheotomy and patients failing to cooperate for different reasons.ĭuring the study, 392 patients were admitted to the G-ICU of these, 214 required MV. The study included patients on mechanical ventilation (MV) for over 12 h, and who in the process of weaning were subjected to low-level pressure support. General intensive care unit (G-ICU) of a third level university hospital. DesignĪ prospective, observational cohort study conducted from 1 September 2010 to 1 March 2011. To determine the value of Vd/ Vt as a predictor of extubation failure in patients with mechanical ventilation admitted to the intensive care units.

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